Ruutu, T. and Gratwohl, A. and de Witte, T. and Afanasyev, B. and Apperley, J. and Bacigalupo, A. and Dazzi, F. and Dreger, P. and Duarte, R. and Finke, J. and Garderet, L. and Greinix, H. and Holler, E. and Kroeger, N. and Lawitschka, A. and Mohty, M. and Nagler, A. and Passweg, J. and Ringden, O. and Socie, G. and Sierra, J. and Sureda, A. and Wiktor-Jedrzejczak, W. and Madrigal, A. and Niederwieser, D. (2014) Prophylaxis and treatment of GVHD: EBMT-ELN working group recommendations for a standardized practice. BONE MARROW TRANSPLANTATION, 49 (2). pp. 168-173. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
GVHD remains the major impediment to broader application of allogeneic haematopoietic SCT. It can be prevented completely, but at the expense of other complications, rejection, relapse or delayed immune reconstitution. No optimal prevention or treatment method has been defined. This is reflected by enormous heterogeneity in approaches in Europe. Retrospective comparisons between different policies, although warranted, do not give definite answers. In order to improve the present situation, an European Group for Blood and Marrow Transplantation and the European LeukemiaNet working group has developed in a Delphi-like approach recommendations for prophylaxis and treatment of GVHD in the most common allogeneic transplant setting, transplantation from an HLA-identical sibling or unrelated donor for standard risk malignant disease. The working group proposes these guidelines to be adopted as routine standard in transplantation centres and to be used as comparator in systematic studies evaluating the advantages and disadvantages of practices differing from these recommendations.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; HEMATOPOIETIC-CELL TRANSPLANTATION; SEVERE APLASTIC-ANEMIA; ACUTE GRAFT; T-CELL; ANTITHYMOCYTE GLOBULIN; MYELOGENOUS LEUKEMIA; RANDOMIZED-TRIAL; UNRELATED DONORS; GVHD; prophylaxis; treatment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Nov 2019 09:00 |
| Last Modified: | 28 Nov 2019 09:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10740 |
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