Forkwa, Tembei K. and Neumann, Inga D. and Tamm, Ernst R. and Ohlmann, Andreas and Reber, Stefan O. (2014) Short-term psychosocial stress protects photoreceptors from damage via corticosterone-mediated activation of the Ala pathway. EXPERIMENTAL NEUROLOGY, 252. pp. 28-36. ISSN 0014-4886, 1090-2430
Full text not available from this repository. (Request a copy)Abstract
Apoptotic death of photoreceptors in hereditary retinal degenerations can be prevented by neuroprotective molecules. Here, we report that adrenal glucocorticoids (GC) released during psychosocial stress protect photoreceptors from apoptosis after light damage. Psychosocial stress is known to be the main type of stressor humans are exposed to and was induced here in mice by 10 h of chronic subordinate colony housing (CSC). Photoreceptor damage was generated by subsequent exposure to white light. Short-term psychosocial stress prior to illumination significantly reduced the number of apoptotic photoreceptors, an effect that was absent in adrenalectomized (ADX) mice. The neuroprotective effect was completely restored in ADX mice substituted with GC. Moreover, phosphorylation of retinal AKT increased following CSC or exogenous GC treatment, an effect that was again absent in ADX mice exposed to CSC. Finally, inhibition of ART signaling with triciribine blocked the stress- and GC-mediated neuroprotective effects on photoreceptors. In summary, we provide evidence that 1) short-term psychosocial stress protects photoreceptors from light-induced damage and 2) the protective effect is most likely mediated by GC-induced activation of the ART signaling pathway. (C) 2013 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDUCED CELL-DEATH; EFFORT-REWARD-IMBALANCE; RETINAL DEGENERATION; PSYCHOLOGICAL STRESS; SURVIVAL SIGNAL; IMMUNE FUNCTION; LIGHT EXPOSURE; MULLER CELLS; IN-VITRO; NEUROPROTECTION; Psychosocial stress; Chronic subordinate colony housing; Hypothalamo-pituitary-adrenocortical axis; Glucocorticoids; Neuroprotection; AKT signaling; Apoptosis; Photoreceptor degeneration; Light-induced photoreceptor damage |
| Subjects: | 500 Science > 570 Life sciences 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Nov 2019 09:36 |
| Last Modified: | 28 Nov 2019 09:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10758 |
Actions (login required)
 |
View Item |
