Aziz, Atiqullah and May, Matthias and Zigeuner, Richard and Pichler, Martin and Chromecki, Thomas and Cindolo, Luca and Schips, Luigi and De Cobelli, Ottavio and Rocco, Bernardo and De Nunzio, Cosimo and Tubaro, Andrea and Coman, Ioan and Truss, Michael and Dalpiaz, Orietta and Hoschke, Bernd and Gilfrich, Christian and Feciche, Bogdan and Fenske, Fabian and Sountoulides, Petros and Figenshau, Robert S. and Madison, Kerry and Sanchez-Chapado, Manuel and Santiago Martin, Maria del Carmen and Wieland, Wolf F. and Salzano, Luigi and Lotrecchiano, Giuseppe and Waidelich, Raphaela and Stief, Christian and Brookman-May, Sabine (2014) Do Young Patients with Renal Cell Carcinoma Feature a Distinct Outcome after Surgery? A Comparative Analysis of Patient Age Based on the Multinational CORONA Database. JOURNAL OF UROLOGY, 191 (2). pp. 310-315. ISSN 0022-5347, 1527-3792
Full text not available from this repository. (Request a copy)Abstract
Purpose: We analyzed the distinct clinicopathological features and prognosis of patients with renal cell carcinoma age 40 years or less compared to a reference group of patients 60 to 70 years old. Materials and Methods: Overall 2,572 patients retrieved from a multicenter international database comprised of 6,234 patients with surgically treated renal cell carcinoma were included in this retrospective study. Clinical and histopathological features of 297 patients 40 years old or younger (4.8%) were compared to those of 2,275 patients (36.5%) 60 to 70 years old, who served as the reference group. Median followup was 59 months. The impact of young age and further parameters on disease specific mortality and all cause mortality was evaluated by multivariate Cox proportional hazards regression analyses. Results: Young patients more frequently underwent nephron sparing surgery (27% vs 20%, p = 0.008) and regional lymph node dissection compared to older patients (38% vs 32%, p = 0.025). Organ confined tumor stage (81% vs 70%, p < 0.001), smaller tumor diameter (4.5 vs 4.7 cm, p = 0.014) and chromophobe subtype (10% vs 4%, p < 0.001) were significantly more frequent in young patients. On multivariate analysis older patients had a higher disease specific (HR 2.21, p < 0.001) and all cause mortality (HR 3.05, p < 0.001). The c indices for the Cox models were 0.87 and 0.78, respectively. However, integration of the variable age group did not significantly increase the predictive accuracy of the disease specific and all cause mortality models. Conclusions: Young patients with renal cell carcinoma (40 years old or younger) have significantly different frequencies of clinical and histopathological features, and a significantly lower all cause and disease specific mortality compared to patients 60 to 70 years old.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INDEPENDENT PROGNOSTIC-FACTOR; CANCER-SPECIFIC SURVIVAL; NATURAL-HISTORY; OLD PATIENTS; ADULTS; TUMORS; ADENOCARCINOMA; BLADDER; STAGE; carcinoma; renal cell; age factors; nephrectomy; neoplasms by histologic type; outcome assessment |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Nov 2019 09:49 |
| Last Modified: | 28 Nov 2019 09:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10767 |
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