Obermajer, Natasa and Popp, Felix C. and Johnson, Christian L. and Benseler, Volker and Dahlke, Marc H. (2014) Rationale and prospects of mesenchymal stem cell therapy for liver transplantation. CURRENT OPINION IN ORGAN TRANSPLANTATION, 19 (1). pp. 60-64. ISSN 1087-2418, 1531-7013
Full text not available from this repository. (Request a copy)Abstract
Purpose of reviewDespite their potential to supplement the donor organ pool, expanded donor criteria grafts are associated with an elevated risk of graft failure and increased early mortality. Likewise, attempts to promote operational graft tolerance through conventional immunosuppressive therapy have demonstrated significant safety-related drawbacks. Because of their potent regenerative and immunomodulative potential, adjunct mesenchymal stem cell (MSC) therapy represents an innovative approach to both of these clinical problems.Recent findingsRecent studies have begun to delineate the benefit and mechanisms of short-term therapy combining MSCs and low-dose immunosuppressive drugs in promoting graft acceptance and potentially regeneration.SummaryThe current review presents our rationale for the first-in-man clinical trial in liver transplantation utilizing a mesenchymal cell product (MultiStem, Athersys, Cleveland, Ohio, USA). The long-term objective of this program is to safely minimize the dose of complementary immunosuppressive drugs while achieving long-term allograft survival and operational tolerance. The use of adjunct cellular therapy as a means of reducing long-term pharmacotherapy would represent a major advancement in the field of liver transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SOLID-ORGAN TRANSPLANTATION; ADULT PROGENITOR CELLS; HEPATOCYTE-LIKE CELLS; REGULATORY T-CELLS; STROMAL CELLS; BONE-MARROW; KIDNEY-TRANSPLANTATION; PRETRANSPLANT INFUSION; ALLOGRAFT TOLERANCE; ACUTE REJECTION; immunosuppression; liver transplantation; mesenchymal stem cells; regeneration; tolerance; transdifferentiation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 21 Jul 2020 08:51 |
| Last Modified: | 21 Jul 2020 08:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10777 |
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