Kokanova-Nedialkova, Zlatina and Kondeva-Burdina, Magdalena and Zheleva-Dimitrova, Dimitrina and Buecherl, Daniel and Nikolov, Stefan and Heilmann, Joerg and Nedialkov, Paraskev T. (2014) A New Acylated Flavonol Glycoside from Chenopodium foliosum. RECORDS OF NATURAL PRODUCTS, 8 (4). pp. 401-406. ISSN 1307-6167,
Full text not available from this repository. (Request a copy)Abstract
A new acylated flavonol glycoside, namely gomphrenol-3-O-(5 '''-O-E-feruloyl)-beta-D-apiofuranosyl-(1 -> 2)[beta-D-glucopyranosyl-(1 -> 6)]-beta-D-glucopyranoside (1) was isolated from the aerial parts of Chenopodium foliosum Asch. The structure of 1 was determined by means of spectroscopic methods (1D and 2D NMR, UV, IR, and HRESIMS). Radical scavenging and antioxidant activities of 1 were established using DPPH and ABTS radicals, FRAP assay and inhibition of lipid peroxidation (LP) in linoleic acid system by the ferric thiocyanate method. Compound 1 showed low activity (DPPH and ABTS) or lack of activity (FRAP and LP). In combination with CCl4, 1 reduced the damage caused by the hepatotoxic agent and preserved cell viability and GSH level, decreased LDH leakage and reduced lipid damage. Effects were concentration dependent, most visible at the highest concentration (100 mu g/mL), and similar to those of silymarin.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ISOLATED HEPATOCYTES; SPINACIA-OLERACEA; LEAVES; Flavonol triglycoside feruloyl ester; Chenopodium; gomphrenol; antioxidant and antihepatotoxic activity |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Nov 2019 13:08 |
| Last Modified: | 28 Nov 2019 13:08 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10882 |
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