Bauer, Richard and Valletta, Daniela and Bauer, Karin and Thasler, Wolfgang E. and Hartmann, Arndt and Mueller, Martina and Reichert, Torsten E. and Hellerbrand, Claus (2014) Downregulation of P-cadherin expression in hepatocellular carcinoma induces tumorigenicity. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 7 (9). pp. 6125-6132. ISSN 1936-2625,
Full text not available from this repository. (Request a copy)Abstract
P-cadherin is a major contributor to cell-cell adhesion in epithelial tissues, playing pivotal roles in important morphogenetic and differentiation processes and in maintaining tissue integrity and homeostasis. Alterations of P-cadherin expression have been observed during the progression of several carcinomas where it appears to act as tumor suppressive or oncogenic in a context-dependent manner. Here, we found a significant downregulation of P-cadherin in hepatocellular carcinoma (HCC) cell lines and tissues compared to primary human hepatocytes and non-malignant liver tissues. Combined immunohistochemical analysis of a tissue microarray containing matched pairs of HCC tissue and corresponding non-tumorous liver tissue of 69 patients confirmed reduced P-cadherin expression in more than half of the cases. In 35 human HCC tissues, the P-cadherin immunosignal was completely lost which correlated with tumor staging and proliferation. Also in vitro, P-cadherin suppression in HCC cells via siRNA induced proliferation compared to cells transfected with control-siRNA. In summary, downregulation of P-cadherin expression appears to induce tumorigenicity in HCC. Therefore, P-cadherin expression may serve as a prognostic marker and therapeutic target of this highly aggressive tumor.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SQUAMOUS-CELL CARCINOMA; ADHESION; ACTIVATION; RECEPTOR; PATHWAY; GROWTH; CANCER; PHENOTYPE; INDICATOR; MIGRATION; P-cadherin; hepatocellular carcinoma; tumor staging; proliferation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 28 Nov 2019 13:56 |
| Last Modified: | 28 Nov 2019 13:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10889 |
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