Bittner, Sebastian and Knoll, Gertrud and Ehrenschwender, Martin (2017) Death receptor 3 signaling enhances proliferation of human regulatory T cells. FEBS LETTERS, 591 (8). pp. 1187-1195. ISSN 1873-3468,
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Exploiting regulatory T cells (Tregs) to control aberrant immune reactions is a promising therapeutic approach, but is hampered by their relative paucity. In mice, activation of death receptor 3 (DR3), a member of the TNF-receptor superfamily (TNFRSF), increases Treg frequency and efficiently controls exuberant immune activation. For human Tregs, neither DR3 expression nor potential functions have been described. Here, we show that human Tregs express DR3 and demonstrate DR3-mediated activation of p38, ERK, and NFjB. DR3 stimulation enhances Treg expansion ex vivo while retaining their suppressive capacity. In summary, our results establish a functional role for DR3 signaling in human Tregs and could potentially help to tailor Treg-based therapies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; ALLERGIC LUNG INFLAMMATION; IFN-GAMMA PRODUCTION; TNF-LIKE LIGAND; MARROW TRANSPLANTATION; PERIPHERAL-BLOOD; TL1A; DR3; EXPRESSION; ACTIVATION; DR3; TL1A; TNFRSF25; TNFSF15; Treg |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 12 Feb 2019 14:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1089 |
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