Breyer, Johannes and Denzinger, Stefan and Otto, Wolfgang and Bruendl, Johannes and Gierth, Michael and Fritsche, Hans-Martin and Roessler, Wolfgang and Wieland, Wolf F. and Giedl, Christian and Hofstaedter, Ferdinand and Rubenwolf, Peter and Burger, Maximilian and Aziz, Atiqullah (2014) Outcome of Patients with Pathological Tumor Stage T3 Urothelial Carcinoma of the Bladder following Radical Cystectomy in a Single-Center Series with 116 Patients. UROLOGIA INTERNATIONALIS, 93 (3). pp. 311-319. ISSN 0042-1138, 1423-0399
Full text not available from this repository. (Request a copy)Abstract
Objective: Outcome prediction of pT3 urothelial carcinoma of the bladder (UCB) after radical cystectomy (RC) remains challenging. The objective of our study was to determine high-risk patients with poor survival outcome in a heterogeneous group substaged pT3 who might profit from early adjuvant chemotherapy. Materials and Methods: We compiled clinicopathological and immunohistochemical data of E-cadherin (E-cad) expression in 116 patients with pT3 UCB after RC in our single-center series. Multivariable Cox regression models including substaged pT3 established clinicopathological features, and the expression of the predictive immunohistochemical feature E-cad was used to identify independent predictors on progression-free (PFS), cancer-specific (CSS) and overall survival (OS), respectively. Results: No significant differences were found addressing clinicopathological data and substaged pT3. In multivariable Cox regression models, lymph node involvement was an independent predictor for PFS (p < 0.001), CSS (p < 0.001) and OS (p = 0.002), respectively. Lymphovascular invasion (LVI) significantly influenced PFS (p = 0.016). ASA score 3/4 independently predicted CSS (p = 0.049) and OS (p = 0.032). Neither pT3 substages nor E-cad expression were significant prognosticators for survival. Conclusions: In pT3 UCB patients with ASA 3/4, positive lymph node status and/or presence of LVI, administration of chemotherapy should be considered due to the high risk of poor oncological outcome. The immunohistochemical marker E-cad was not an independent predictor. (C) 2014 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROSS EXTRAVESICAL EXTENSION; TRANSITIONAL-CELL CARCINOMA; E-CADHERIN; LYMPHOVASCULAR INVASION; EXTERNAL VALIDATION; PROGNOSTIC VALUE; CANCER; RECURRENCE; SURVIVAL; LYMPHADENECTOMY; Bladder carcinoma; E-cadherin; Pathological stage T3; Pathology; Prognostic factors; Radical cystectomy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2019 08:01 |
| Last Modified: | 29 Nov 2019 08:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10918 |
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