Karagiannidis, Christian and Kampe, Kristin Aufm and Suarez Sipmann, Fernando and Larsson, Anders and Hedenstierna, Goran and Windisch, Wolfram and Mueller, Thomas (2014) Veno-venous extracorporeal CO2 removal for the treatment of severe respiratory acidosis: pathophysiological and technical considerations. CRITICAL CARE, 18 (3): R124. ISSN 1466-609X, 1364-8535
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Introduction: While non-invasive ventilation aimed at avoiding intubation has become the modality of choice to treat mild to moderate acute respiratory acidosis, many severely acidotic patients (pH <7.20) still need intubation. Extracorporeal veno-venous CO2 removal (ECCO2R) could prove to be an alternative. The present animal study tested in a systematic fashion technical requirements for successful ECCO2R in terms of cannula size, blood and sweep gas flow. Methods: ECCO2R with a 0.98 m(2) surface oxygenator was performed in six acidotic (pH <7.20) pigs using either a 14.5 French (Fr) or a 19Fr catheter, with sweep gas flow rates of 8 and 16 L/minute, respectively. During each experiment the blood flow was incrementally increased to a maximum of 400 mL/minute (14.5Fr catheter) and 1000 mL/minute (19Fr catheter). Results: Amelioration of severe respiratory acidosis was only feasible when blood flow rates of 750 to 1000 mL/minute (19Fr catheter) were used. Maximal CO2-elimination was 146.1 +/- 22.6 mL/minute, while pH increased from 7.13 +/- 0.08 to 7.41 +/- 0.07 (blood flow of 1000 mL/minute; sweep gas flow 16 L/minute). Accordingly, a sweep gas flow of 8 L/minute resulted in a maximal CO2-elimination rate of 138.0 +/- 16.9 mL/minute. The 14.5Fr catheter allowed a maximum CO2 elimination rate of 77.9 mL/minute, which did not result in the normalization of pH. Conclusions: Veno-venous ECCO2R may serve as a treatment option for severe respiratory acidosis. In this porcine model, ECCO2R was most effective when using blood flow rates ranging between 750 and 1000 mL/minute, while an increase in sweep gas flow from 8 to 16 L/minute had less impact on ECCO2R in this setting.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CARBON-DIOXIDE REMOVAL; POSITIVE-PRESSURE VENTILATION; OBSTRUCTIVE PULMONARY-DISEASE; INTERVENTIONAL LUNG ASSIST; NONINVASIVE VENTILATION; MECHANICAL VENTILATION; 6 ML/KG; FAILURE; EXACERBATIONS; COPD; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2019 09:03 |
| Last Modified: | 29 Nov 2019 09:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10943 |
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