Keusch, Stephan and Hildenbrand, Florian F. and Bollmann, Tom and Halank, Michael and Held, Matthias and Kaiser, Ralf and Kovacs, Gabor and Lange, Tobias J. and Seyfarth, Hans-Juergen and Speich, Rudolf and Ulrich, Silvia (2014) Tobacco Smoke Exposure in Pulmonary Arterial and Thromboembolic Pulmonary Hypertension. RESPIRATION, 88 (1). pp. 38-45. ISSN 0025-7931, 1423-0356
Full text not available from this repository. (Request a copy)Abstract
Background: Animal studies and data from a single-center study suggest that tobacco smoke exposure may be a risk factor for precapillary pulmonary hypertension (PH). Objective: We aimed to survey tobacco smoke exposure in a large PH collective and to compare it with epidemiological data from healthy subjects. Methods: This is an international, multicenter, case-control study including patients with pulmonary arterial and chronic thromboembolic PH. All patients were asked specific questions about tobacco smoke exposure. Healthy controls were retrieved from the Swiss Health Survey (n = 18,747). Results: Overall (n = 472), 49% of PH patients were smokers and there was a clear sex difference (women 37%, men 71%). Significantly more PH men were smokers compared with healthy controls, whereas less PH women were ever active smokers. However, 50% of the non-smoking PH women were exposed to secondhand smoke, leading to a significantly higher number of tobacco smoke-exposed individuals compared to healthy controls. PH smokers were significantly younger compared to those not exposed. Conclusion: Active and environmental tobacco smoke exposure is common in PH. The higher prevalence of male PH smokers, the higher exposure to environmental tobacco smoke in PH women compared to healthy controls and the lower age at PH diagnosis in smokers may indicate a pathogenic role of tobacco smoke exposure in PH. (C) 2014 S. Karger AG, Basel
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CIGARETTE-SMOKE; GUINEA-PIG; VASOACTIVE MEDIATORS; DISEASE; RISK; COPD; SUSCEPTIBILITY; OBSTRUCTION; DIAGNOSIS; WOMEN; Chronic thromboembolic pulmonary hypertension; Pulmonary hypertension; Pulmonary arterial hypertension; Tobacco smoke; Smoking; Risk factor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2019 08:55 |
| Last Modified: | 29 Nov 2019 08:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10971 |
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