Straub, Rainer H. (2014) Systemic disease sequelae in chronic inflammatory diseases and chronic psychological stress: comparison and pathophysiological model. STEROIDS IN NEUROENDOCRINE IMMUNOLOGY AND THERAPY OF RHEUMATIC DISEASES II, 1318. pp. 7-17. ISSN 0077-8923,
Full text not available from this repository. (Request a copy)Abstract
In chronic inflammatory diseases (CIDs), the neuroendocrine-immune crosstalk is important to allocate energy-rich substrates to the activated immune system. Since the immune system can request energy-rich substrates independent of the rest of the body, I refer to it as the "selfish immune system," an expression that was taken from the theory of the "selfish brain," giving the brain a similar position. In CIDs, the theory predicts the appearance of long-term disease sequelae, such as metabolic syndrome. Since long-standing energy requirements of the immune system determine disease sequelae, the question arose as to whether chronic psychological stress due to chronic activation of the brain causes similar sequelae. Indeed, there are many similarities; however, there are also differences. A major difference is the behavior of body weight (constant in CIDs versus loss or gain in stress). To explain this discrepancy, a new pathophysiological theory is presented that places inflammation and stress axes in the middle.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BODY-MASS INDEX; EARLY RHEUMATOID-ARTHRITIS; PITUITARY-ADRENAL AXIS; TUMOR-NECROSIS-FACTOR; SYMPATHETIC-NERVE FIBERS; GLUCOCORTICOID-RECEPTOR; ENERGY-EXPENDITURE; IN-VITRO; ADRENOCORTICAL AXIS; PSYCHOSOCIAL STRESS; chronic inflammatory disease; rheumatoid arthritis; psychological stress; systemic disease sequelae |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Dec 2019 12:09 |
| Last Modified: | 05 Dec 2019 12:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10978 |
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