Wankerl, B. and Hauser, J. and Makulska-Gertruda, E. and Reissmann, A. and Sontag, T. A. and Tucha, O. and Lange, K. W. (2014) Neurobiology of Attention Deficit Hyperactivity Disorder. FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE, 82 (1). ISSN 0720-4299, 1439-3522
Full text not available from this repository. (Request a copy)Abstract
The origin of ADHD is multifactorial and both the aetiology and pathophysiology of ADHD are as yet incompletely understood. The monoamine deficit hypothesis of ADHD postulates a dysbalance in the interaction of the neurotransmitters dopamine, noradrenaline and serotonin. Pathophysiological mechanisms involved in ADHD include alterations in fronto-striatal circuits. The currently proposed animal models of ADHD are heterogeneous with regard to their pathophysiological alterations and their ability to mimic behavioural symptoms and to predict response to medication. Some evidence points to a genetic basis for ADHD which is likely to involve many genes of small individual effects. In summary, specific neurobiological substrates of ADHD are unknown and multiple genetic and environmental factors appear to act together to create a spectrum of neurobiological liability.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENOME-WIDE ASSOCIATION; SPONTANEOUSLY HYPERTENSIVE-RAT; DUAL PATHWAY MODEL; ALTERED REINFORCEMENT MECHANISMS; STRIATAL DOPAMINE TRANSPORTER; GENE-ENVIRONMENT INTERACTION; WHITE-MATTER ABNORMALITIES; EVENT-RELATED POTENTIALS; SCHOOL-AGED CHILDREN; OPEN-FIELD BEHAVIOR; attention deficit hyperactivity disorder; ADHD; neurobiology; pathophysiology; genetics; animal models |
| Subjects: | 100 Philosophy & psychology > 150 Psychology |
| Divisions: | Psychology and Pedagogy > Institut für Psychologie > Lehrstuhl für Psychologie III (Biologische, Klinische und Rehabilitationspsychologie) - Prof. Dr. Klaus W. Lange |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2019 10:13 |
| Last Modified: | 29 Nov 2019 10:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10984 |
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