Cutolo, Maurizio and Sulli, Alberto and Straub, Rainer H. (2014) Estrogen's effects in chronic autoimmune/inflammatory diseases and progression to cancer. EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 10 (1). pp. 31-39. ISSN 1744-666X, 1744-8409
Full text not available from this repository. (Request a copy)Abstract
Endocrine-immune system interactions are the basis for predominance of autoimmune diseases in women with differences between the fertile and the postmenopausal periods. B cell-driven diseases reach the maximum incidence rate in the reproductive years, at least in women under the effects of serum estrogens and their metabolites (endocrine synthesis). On the other hand, the prevalent peripheral synthesis of estrogens, especially in advanced ages (intracrine synthesis), through the action of aromatases, modulate the immune/inflammatory response in peripheral tissues similarly in both female and male patients (final common pathway). Interestingly, tissue injury that occurs during chronic immune/inflammatory reaction induces tissue repair and homeostatic responses including cell proliferation, growth factor production and angiogenesis that might facilitate cancer progression. The successful treatment of chronic immune/inflammatory diseases obtained by using medications initially developed for use in oncology, such as antiproliferative drugs, B-cell depleting monoclonal antibodies support the inflammation-cancer link.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SYSTEMIC-LUPUS-ERYTHEMATOSUS; RHEUMATOID-ARTHRITIS; SEX-HORMONES; AROMATASE EXPRESSION; CIRCADIAN-RHYTHMS; MODIFIED DNA; THERAPY; AUTOIMMUNITY; LEFLUNOMIDE; METABOLISM; cancer; chronic autoimmune diseases; circadian rhythms; endocrine; immune system; estrogens; rheumatoid arthritis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2019 09:56 |
| Last Modified: | 29 Nov 2019 09:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/10991 |
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