Luo, Chonglin and Weber, Claudia E. M. and Osen, Wolfram and Bosserhoff, Anja-Katrin and Eichmueller, Stefan B. (2014) The role of microRNAs in melanoma. EUROPEAN JOURNAL OF CELL BIOLOGY, 93 (1-2). pp. 11-22. ISSN 0171-9335, 1618-1298
Full text not available from this repository. (Request a copy)Abstract
Melanoma is the most dangerous form of skin cancer, being largely resistant to conventional therapies at advanced stages. Understanding the molecular mechanisms behind this disease might be the key for the development of novel therapeutic strategies. MicroRNAs (miRNAs) are small non-coding RNAs that post-transcriptionally control gene expression, thereby regulating various cellular signaling pathways involved in the initiation and progression of different cancer types, including melanoma. In this review, we summarize approaches for the identification of candidate miRNAs and their target genes and review the functions of miRNAs in melanoma. Finally, we highlight the recent progress in pre-clinical use of miRNAs as prognostic markers and therapeutic targets. (C) 2014 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN LUNG CANCERS; EXPRESSION PROFILES; MALIGNANT-MELANOMA; TUMOR-SUPPRESSOR; DOWN-REGULATION; DIFFERENTIAL EXPRESSION; CIRCULATING MICRORNAS; EPIGENETIC REGULATION; CELL-PROLIFERATION; GENE-EXPRESSION; Melanoma; MicroRNA; Expression profiling; Target identification; Bioinformatics; Oncogene; Tumor suppressor; Diagnosis; Tumor marker; Therapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jul 2020 10:54 |
| Last Modified: | 17 Jul 2020 10:54 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11013 |
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