Opekarova, Miroslava and Tanner, Widmar (2014) Membrane Transport Inhibition as Mode of Action of Polyene Antimycotics: Recent Data Supported by Old Ones. FOOD TECHNOLOGY AND BIOTECHNOLOGY, 52 (1). pp. 8-12. ISSN 1330-9862, 1334-2606
Full text not available from this repository. (Request a copy)Abstract
Recent studies demonstrate that the actual interactions of polyenes with membrane sterols are the basis for their antimycotic toxicity and not, as previously assumed, their potential to form pores. Therefore, sterols must play a vital role in membranes and this function is seriously disturbed once polyenes bind to and/or sequester them. Essential membrane proteins obviously require sterols for their activity. Among the various membrane. protein/ergosterol interactions discussed herein, transport proteins of the plasma membrane are most likely the primary target for polyenes. All data available which support this notion are summarized in this review. Even data obtained almost 40 years ago could be useful in guiding future research.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SACCHAROMYCES-CEREVISIAE; PLASMA-MEMBRANE; ANTIFUNGAL AGENTS; YEAST; ERGOSTEROL; NYSTATIN; COMPARTMENTATION; ANTIBIOTICS; ENDOCYTOSIS; METABOLISM; amphotericin B; nystatin; natamycin; sugar and amino acid transport |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Pflanzenwissenschaften |
| Depositing User: | Petra Gürster |
| Date Deposited: | 17 Jul 2020 10:51 |
| Last Modified: | 17 Jul 2020 10:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11024 |
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