Fredersdorf, Sabine and Uecer, Ekrem and Jungbauer, Carsten and Dornia, Christian and Eglmeier, Julia and Eissnert, Christoph and Hamer, Okka W. and Weber, Stefan and Arzt, Michael and von Bary, Christian (2014) Lone atrial fibrillation as a positive predictor of left atrial volume reduction following ablation of atrial fibrillation. EUROPACE, 16 (1). pp. 26-32. ISSN 1099-5129, 1532-2092
Full text not available from this repository. (Request a copy)Abstract
Aims We investigated predictors of left atrial volume reduction (LAVR) in patients with atrial fibrillation (AF) undergoing AF ablation. Methods and results Sixty patients with AF underwent pulmonary vein isolation (PVI) using a pulmonary vein ablation catheter (PVAC). All patients underwent cardiac imaging by computed tomography or magnetic resonance imaging to determine LAV 1 day before and 140 +/- 9.5 days after PVI. Clinical follow-up and 72 h electrocardiogram Holter monitoring were performed 1, 3, and 6 months after ablation, and every 6 months thereafter. Significant LAVR (n = 60, 89.3 +/- 3.9 vs. 79.5 +/- 3.6 mL, P < 0.0001) was shown for the study group as a whole, caused particularly by the subgroup of patients with ablation success (n = 45, 85.2 +/- 4.6 vs. 72.5 +/- 3.7 mL, P < 0.0001). In addition, significant LAVR was shown for patients with lone AF (n = 25, 88.8 +/- 6.8 vs. 72.7 +/- 5.3 mL, P < 0.0001), but not for patients with AF and concomitant arterial hypertension (n = 32, 89 +/- 4.8 vs. 86.7 +/- 5 mL, P = 0.3), coronary artery disease (n = 12, 91.6 +/- 7.8 vs. 89.1 +/- 7.8 mL, P = 0.26), or left ventricular hypertrophy (n = 10, 86.3 +/- 5.5 vs. 83.1 +/- 5.3 mL, P = 0.27). Multivariate analysis revealed absence of arterial hypertension, lone AF, ablation success, and initial LA enlargement as independent predictors for significant LAVR following ablation (each P < 0.05). Conclusion Based on the subgroup of patients with lone AF, PVI leads to a significant LAVR 4 months after the procedure, especially in patients with clinical success in terms of AF freedom. Comorbidities such as arterial hypertension may prevent this reverse atrial remodelling, despite AF freedom. Clinical implications need to be further elucidated.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PULMONARY VEIN ISOLATION; MAGNETIC-RESONANCE ANGIOGRAPHY; CATHETER ABLATION; COMPUTED-TOMOGRAPHY; ECHOCARDIOGRAPHY; INJURY; PVAC; MRI; Arterial hypertension; Lone atrial fibrillation; Clinical predictor; Left atrial volume reduction; Ablation for atrial fibrillation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Nov 2019 11:40 |
| Last Modified: | 29 Nov 2019 11:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11045 |
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