Sarubin, Nina and Nothdurfter, Caroline and Schmotz, Christian and Wimmer, Anna-Maria and Trummer, Julia and Lieb, Martin and Uhr, Manfred and Baghai, Thomas C. and Wetter, Thomas C. and Buehner, Markus and Rupprecht, Rainer and Schuele, Cornelius (2014) Impact on cortisol and antidepressant efficacy of quetiapine and escitalopram in depression. PSYCHONEUROENDOCRINOLOGY, 39. pp. 141-151. ISSN 0306-4530,
Full text not available from this repository. (Request a copy)Abstract
Background: In this study, the impact of quetiapine fumarate extended release (QXR) and escitalopram (ESC) on HPA axis activity was investigated in depressed patients in relationship to antidepressant efficacy. Methods: In a randomized, open-label 5-week trial 60 inpatients suffering from major depression (DSM-IV criteria) were treated for 5 weeks with either QXR (300 mg/day) or ESC (10 mg/day). The dexamethasone/CRH (DEX/CRH) test was performed before treatment, after 1, and after 5 weeks of treatment. Cortisol (COR) AUC values were used to assess HPA axis function. The Hamilton Depression Rating Scale was used weekly to estimate antidepressant efficacy. Results: QXR and ESC showed comparable antidepressant effects but strongly differed in their impact on HPA axis activity. In the QXR group, a marked inhibition of COR AUC levels was observed which was most pronounced after one week of treatment but showed a partial re-increase after 5 weeks of treatment. In contrast, ESC transiently stimulated COR AUC values (week 1) whereas COR AUC levels at week 0 and week 5 were comparable. COR improvement at week 1 (defined as COR peak value reduction between DEX/CRH test 1 and 2) was significantly associated with better clinical outcome. Conclusion: Apparently, different effects on HPA axis activity reflect distinct pharmacoendocrinological properties of psychotropic drugs. (C) 2013 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COMBINED DEXAMETHASONE/CRH TEST; TREATMENT-RESISTANT DEPRESSION; CORTICOTROPIN-RELEASING HORMONE; MESSENGER-RNA EXPRESSION; PLACEBO-CONTROLLED TRIAL; DEX-CRH TEST; MAJOR DEPRESSION; DOUBLE-BLIND; FUMARATE MONOTHERAPY; TREATMENT RESPONSE; Major depression; Escitalopram; Quetiapine; HPA system |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2019 10:01 |
| Last Modified: | 02 Dec 2019 10:01 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11061 |
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