Buchner, Stefan and Satzl, Anna and Debl, Kurt and Hetzenecker, Andrea and Luchner, Andreas and Husser, Oliver and Hamer, Okka W. and Poschenrieder, Florian and Fellner, Claudia and Zeman, Florian and Riegger, Guenter A. J. and Pfeifer, Michael and Arzt, Michael (2014) Impact of sleep-disordered breathing on myocardial salvage and infarct size in patients with acute myocardial infarction. EUROPEAN HEART JOURNAL, 35 (3). pp. 192-199. ISSN 0195-668X, 1522-9645
Full text not available from this repository. (Request a copy)Abstract
Sleep-disordered breathing (SDB) may be a risk factor for expansion of infarct size early after acute myocardial infarction (MI) by exposing the heart to repetitive oxygen desaturations and increased cardiac afterload. The objective of this study was to assess the impact of SDB on myocardial salvage and infarct size within 3 months after acute MI. Patients with acute MI and percutaneous coronary intervention were enrolled in this prospective observational study. All patients underwent cardiovascular magnetic resonance (CMR) to define salvaged myocardium and infarct size within three to five days and at 3 months after acute MI. Patients were stratified according to apnoeahypopnoea index (AHI) assessed by polysomnography at baseline into those with (AHI 15/h) and without (AHI 15/h) SDB. Of the 56 patients included, 29 (52) had SDB. The area at risk between both groups was similar (40 12 vs. 40 14, P 0.925). Patients with SDB had significantly less salvaged myocardium (myocardial salvage index 52 vs. 77, P 0.001), smaller reduction in infarct size (0.3 vs. 6.5, P 0.001) within 3 months after acute MI, a larger final infarct size (23 vs. 12, P 0.001), and a lower final left ventricular ejection fraction (48 vs. 54, P 0.023). In a multivariate analysis, including established risk factors for large MI, AHI was independently associated with less myocardial salvage and a larger infarct size 3 months after acute MI. Sleep-disordered breathing was associated with less myocardial salvage and a smaller reduction in infarct size. These findings suggest a contribution of SDB to impaired healing of MI.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC INTERMITTENT HYPOXIA; CARDIOVASCULAR MAGNETIC-RESONANCE; LEFT-VENTRICULAR FUNCTION; CORONARY-ARTERY-DISEASE; VASCULAR REACTIVITY; EJECTION FRACTION; OXIDATIVE STRESS; HEART-FAILURE; APNEA; RECOVERY; Myocardial infarction; Sleep apnoea; Magnetic resonance imaging; Heart failure |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Zentren des Universitätsklinikums Regensburg > Zentrum für Klinische Studien |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Dec 2019 10:14 |
| Last Modified: | 02 Dec 2019 10:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11066 |
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