Schneckenpointner, R. and Joerres, R. A. and Meidenbauer, N. and Kollert, F. and Pfeifer, M. and Budweiser, S. (2014) The clinical significance of anaemia and disturbed iron homeostasis in chronic respiratory failure. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 68 (1). pp. 130-138. ISSN 1368-5031, 1742-1241
Full text not available from this repository. (Request a copy)Abstract
BackgroundAnaemia is a frequent, clinically relevant condition in various chronic diseases. It seems also to be prevalent in patients with chronic respiratory failure (CRF). We studied the characteristics of anaemia in CRF and its associations with clinical outcome. MethodsIn a prospective design, 271 consecutive patients with CRF were evaluated; patients with other conditions often associated with anaemia were excluded. Haematological laboratory and physiological parameters, health-related quality of life (HRQL), dyspnoea and 48-month survival were determined. Anaemia was defined according to WHO [haemoglobin (Hb)<13g/l (male); Hb<12g/dl (female)] and using an established algorithm. ResultsAmong 185 patients included, 18.4% showed anaemia, not depending on chronic obstructive pulmonary disease (COPD) vs. non-COPD (17.6% vs. 19.0%; p=0.851) or on gender [16.5% (female) vs. 19.8% (male); p=0.702]. Anaemic patients had higher age, creatinine (p<0.05 each) and erythropoietin levels (p<0.001), but lower transferrin saturation (TSAT), serum iron and vitamin B-12 levels (p<0.01 each). By definition, most anaemic patients (67.6%) had disturbances in iron homeostasis according to anaemia of chronic disease' and/or true iron deficiency anaemia. Hb was independently related to dyspnoea and HRQL, while TSAT 20% was linked to less dyspnoea and better subjective exercise capability. Non-survivors had lower Hb and serum iron levels (p<0.05 each). In multivariate analysis, lower serum iron levels and TSAT were independently associated with mortality (p<0.05 each). ConclusionAnaemia was common in patients with CRF and often because of disturbed iron homeostasis. Hb and TSAT were linked to functional outcome and HRQL. Lower serum iron levels and TSAT were independent prognostic parameters.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OBSTRUCTIVE PULMONARY-DISEASE; CHRONIC HEART-FAILURE; QUALITY-OF-LIFE; KIDNEY-DISEASE; COPD; PREVALENCE; DEFICIENCY; IMPACT; ASSOCIATION; MANAGEMENT; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Dec 2019 15:02 |
| Last Modified: | 03 Dec 2019 15:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11119 |
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