Riescher, Sebastian and Wehner, Daniel and Schmid, Thomas and Zimmermann, Hanngoerg and Hartmann, Bjoern and Schmid, Christof and Lehle, Karla (2014) Titaniumcarboxonitride layer increased biocompatibility of medical polyetherurethanes. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 102 (1). pp. 141-148. ISSN 1552-4973, 1552-4981
Full text not available from this repository. (Request a copy)Abstract
Polyetherurethane (PEU) is in use for blood-contacted devices because of its excellent mechanical properties. However, poor hemocompatibility of the hydrophobic material required surface modification or endothelialization. To increase the biocompatibility of PEU, the polymer was coated with a titaniumcarboxonitride [Ti(C,N,O)] layer by a plasma-activated chemical vapor deposition (PACVD) process. Biocompatibility of titaniferously coated PEU was verified using static and dynamic cell culture techniques. Titaniferous coating significantly improved proliferation and mitochondrial activity of human endothelial cells on PEU. These cells captured significantly less mononuclear cells and platelets. Under shear stress for up to 72 hours, titaniferous coating increased endothelial cell adhesion, spreading, and cell density to form an organized monolayer covering the whole luminal surface of vascular PEU grafts. In summary, coating of PEU surfaces with Ti(C,N,O) might be a promising strategy to improve the biocompatibility of biomedical biomaterials. (c) 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 141-148, 2014.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN ENDOTHELIAL-CELLS; IN-VIVO; TITANIUM; ADHESION; BLOOD; SURFACES; POLYURETHANES; POLYMERS; IMPLANTS; DEVICES; endothelial cell seeding; platelet adhesion; bioreactor; tissue engineering; titanium |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Dec 2019 15:13 |
| Last Modified: | 03 Dec 2019 15:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11125 |
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