Xylinas, Evanguelos and Rink, Michael and Cha, Eugene K. and Clozel, Thomas and Lee, Richard K. and Fajkovic, Harun and Comploj, Evi and Novara, Giacomo and Margulis, Vitaly and Raman, Jay D. and Lotan, Yair and Kassouf, Wassim and Fritsche, Hans-Martin and Weizer, Alon and Martinez-Salamanca, Juan I. and Matsumotom, Kazumasa and Zigeuner, Richard and Pycha, Armin and Scherr, Douglas S. and Seitz, Christian and Walton, Thomas and Quoc-Dien Trinh, and Karakiewicz, Pierre I. and Matin, Surena and Montorsi, Francesco and Zerbib, Marc and Shariat, Shahrokh F. (2014) Impact of Distal Ureter Management on Oncologic Outcomes Following Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma. EUROPEAN UROLOGY, 65 (1). pp. 210-217. ISSN 0302-2838, 1873-7560
Full text not available from this repository. (Request a copy)Abstract
Background: There is a lack of consensus regarding the optimal approach to the bladder cuff during radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). Objectives: To compare the oncologic outcomes following RNU using three different methods of bladder cuff management. Design, setting, and participants: Retrospective analysis of 2681 patients treated with RNU for UTUC at 24 international institutions from 1987 to 2007. Intervention: Three methods of bladder cuff excision were performed: transvesical, extravesical, and endoscopic. Outcome measurements and statistical analysis: Univariable and multivariable models tested the effect of distal ureter management on intravesical recurrence, recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS). Results and limitations: Of the 2681 patients, 1811 (67.5%) underwent the transvesical approach; 785 (29.3%), the extravesical approach; and 85 (3.2%), the endoscopic approach. There was no difference in terms of RFS, CSS, and OS among the three distal ureteral management approaches. Patients who underwent the endoscopic approach were at significantly higher risk of intravesical recurrence compared with those who underwent the transvesical (p = 0.02) or extravesical approaches (p = 0.02); the latter two groups did not differ from each other (p = 0.40). Actuarial intravesical RFS estimates at 2 and 5 yr after RNU were 69% and 58%, 69% and 51%, and 61% and 42% for the transvesical, extravesical, and endoscopic approaches, respectively. In multivariate analyses, distal ureteral management (p = 0.01), surgical technique (open vs laparoscopic; p = 0.02), previous bladder cancer (p < 0.001), higher tumor stage (trend; p = 0.01), concomitant carcinoma in situ (CIS) (p < 0.001), and lymph node involvement (trend; p < 0.001) were all associated with intravesical recurrence. Excluding patients with history of previous bladder cancer, all variables remained independent predictors of intravesical recurrence. Conclusions: The endoscopic approach was associated with higher intravesical recurrence rates. Interestingly, concomitant CIS in the upper tract is a strong predictor of intravesical recurrence after RNU. The association of laparoscopic RNU with intravesical recurrence needs to be further investigated. (C) 2012 European Association of Urology. Published by Elsevier B. V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LAPAROSCOPIC NEPHROURETERECTOMY; PROGNOSTIC-FACTORS; BLADDER CUFF; TUMOR; RECURRENCE; SURVIVAL; Upper tract urothelial carcinoma; Radical nephroureterectomy; Distal ureter management; Recurrence |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Dec 2019 15:17 |
| Last Modified: | 03 Dec 2019 15:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/11136 |
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