Spuls, P. I. and Gerbens, L. A. A. and Simpson, E. and Apfelbacher, C. J. and Chalmers, J. R. and Thomas, K. S. and Prinsen, C. A. C. and von Kobyletzki, L. B. and Singh, J. A. and Williams, H. C. and Schmitt, J. (2017) Patient-Oriented Eczema Measure (POEM), a core instrument to measure symptoms in clinical trials: a Harmonising Outcome Measures for Eczema (HOME) statement. BRITISH JOURNAL OF DERMATOLOGY, 176 (4). pp. 979-984. ISSN 0007-0963, 1365-2133
Full text not available from this repository. (Request a copy)Abstract
Background The Harmonising Outcome Measures for Eczema (HOME) initiative has defined four core outcome domains for a core outcome set (COS) to be measured in all atopic eczema (AE) trials to ensure cross-trial comparison: clinical signs, symptoms, quality of life and long-term control. Objectives The aim of this paper is to report on the consensus process that was used to select the core instrument to consistently assess symptoms in all future AE trials. Methods Following the HOME roadmap, two systematic reviews were performed which identified three instruments that had sufficient evidence of validity, reliability and feasibility to be considered for the final COS. Results At the fourth international HOME meeting, there was broad consensus among all stakeholders that the Patient-Oriented Eczema Measure (POEM) should be used as the core instrument (87.5% agreed, 9.4% unsure, 3.1% disagreed). Conclusions All relevant stakeholders are encouraged to use POEM as the chosen instrument to measure the core domain of symptoms in all future AE clinical trials. Other instruments of interest can be used in addition to POEM.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATOPIC-DERMATITIS SEVERITY; CONSENSUS; QUALITY; SCORAD; DELPHI; SIGNS; SETS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 12 Feb 2019 14:12 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1135 |
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