Volz, Martin and Schaumburger, Jens and Frick, Hubert and Grifka, Joachim and Anders, Sven (2017) A randomized controlled trial demonstrating sustained benefit of Autologous Matrix-Induced Chondrogenesis over microfracture at five years. INTERNATIONAL ORTHOPAEDICS, 41 (4). pp. 797-804. ISSN 0341-2695, 1432-5195
Full text not available from this repository. (Request a copy)Abstract
Purpose Autologous Matrix-Induced Chondrogenesis (AMIC(A (R))) utilizing a type I/III collagen membrane was compared with microfracture (MFx) alone in focal cartilage lesions of the knee at one, two and five years. Methods Forty-seven patients (aged 37 +/- 10 years, mean defect size 3.6 +/- 1.6 cm(2)) were randomized and treated either with MFx, with sutured or glued AMIC(A (R)) in a prospective multicentre clinical trial. Results After improvement for the first two years in all subgroups, a progressive and significant score degradation was observed in the MFx group, while all functional parameters remained stable for least five years in the AMIC(A (R)) groups. At two and five years, MRI defect filling was more complete in the AMIC(A (R)) groups. No treatment-related adverse events were reported. Conclusions AMIC(A (R)) is an effective cartilage repair procedure in the knee resulting in stable clinical results significantly better than the MFx group at five years.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTICULAR-CARTILAGE DEFECTS; CHONDROCYTE IMPLANTATION; CHONDRAL DEFECTS; FOLLOW-UP; KNEE; REPAIR; OSTEOARTHRITIS; METAANALYSIS; OUTCOMES; SURGERY; Articular cartilage; Autologous Matrix-Induced Chondrogenesis (AMIC (R)); Chondro-Gide (R); Knee surgery; Microfracture |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 18 Feb 2019 14:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1141 |
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