Guter, Michaela and Breunig, Miriam (2017) Hyaluronan as a promising excipient for ocular drug delivery. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 113. pp. 34-49. ISSN 0939-6411, 1873-3441
Full text not available from this repository. (Request a copy)Abstract
Hyaluronan (HA) is a naturally occurring polysaccharide and well known for its exceptional properties such as high biocompatibility and biodegradability, along with a low immunogenicity. Besides its use for various biomedical applications it recently came into focus as a favorable excipient for the formulation of various ocular therapeutics. This review article summarizes the ocular distribution of HA and its most heavily investigated binding protein "cluster of differentiation 44" (CD44) which is the rationale for the clinical use of HA, primarily as an additive in ocular applications ranging from eye drops to contact lenses. Moreover, examples will be given for using HA in various pre-clinical approaches to generate entirely new therapeutics, most notably in the field of nanotechnology. (C) 2016 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RETINAL-PIGMENT EPITHELIUM; OPEN-ANGLE GLAUCOMA; DRY EYE DISEASE; ARTIFICIAL VITREOUS SUBSTITUTE; ACID-TYRAMINE HYDROGELS; INTERNAL WETTING AGENT; ADHESION MOLECULE CD44; AQUEOUS-HUMOR SCD44; TEAR FILM THICKNESS; CELLS IN-VITRO; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 22 Sep 2020 05:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1161 |
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