Wichner, Dominik and Idris, Hamidah and Houssen, Wael E. and McEwan, Andrew R. and Bull, Alan T. and Asenjo, Juan A. and Goodfellow, Michael and Jasparsi, Marcel and Ebell, Rainer and Rateb, Mostafa E. (2017) Isolation and anti-HIV-1 integrase activity of Ientzeosides A-F from extremotolerant lentzea sp H45, a strain isolated from a high-altitude Atacama Desert soil. JOURNAL OF ANTIBIOTICS, 70 (4). pp. 448-453. ISSN 0021-8820,
Full text not available from this repository. (Request a copy)Abstract
The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A-F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1-6 displayed moderate inhibitory activity against HIV integrase.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STREPTOMYCES SP; HIV-1 INTEGRASE; SP NOV.; GLYCOSIDES; CHILE; MICROBIOLOGY; CHAXAMYCINS; GENUS; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:11 |
| Last Modified: | 28 Feb 2019 13:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1163 |
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