Azevedo, Andreia Aparecida and Figueiredo, Ricardo Rodrigues and Elgoyhen, Ana Belen and Langguth, Berthold and Penido, Norma De Oliveira and Schlee, Winfried (2017) Tinnitus Treatment with Oxytocin: A Pilot Study. FRONTIERS IN NEUROLOGY, 8: 494. ISSN 1664-2295,
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Introduction: Tinnitus is the perception of sound in the absence of an external stimulus. It is a frequent condition for which there is as yet no pharmacological treatment approved. Auditory and non-auditory pathways are involved in tinnitus' pathophysiology. Oxytocin is a neurohormone and eventual neurotransmitter that plays a complex role in social cognition and behavior. Objective: To evaluate the potential of oxytocin as a tinnitus treatment. Study design: Two studies were performed. Study 1 was a long-term open pilot study, while study 2 investigated short-term effects with a double-blinded placebo-controlled cross-over study. Setting: Ambulatory ENT care. Subjects and method: In study 1, 15 patients were investigated over a 10-week period in an open pilot study. In study 2, 16 patients were included in a placebo-controlled crossover trial to investigate short-term effects following a single dose. Results: For the long-term study (study 1), analysis of variance revealed a significant decrease in tinnitus sensation, both for the Tinnitus Handicap Inventory and Clinical Global Impression (CGI). Also, the short-term effects in study 2 revealed a significant reduction of tinnitus because of the oxytocin nasal spray as measured with the Visual Analog Scale and the CGI Scale. Conclusion: These preliminary studies demonstrated that oxytocin may represent a helpful tool for treating tinnitus and further larger controlled studies are warranted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MATERNAL-BEHAVIOR; CLINICAL-TRIALS; DISTRESS; PAIN; VASOPRESSIN; SEVERITY; NETWORKS; HUMANS; SYSTEM; tinnitus; oxytocin; hearing disorders; pharmacotherapy; nasal sprays |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 21 Feb 2019 14:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1169 |
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