Dukhno, Oleksii and Przybilla, Frederic and Collot, Mayeul and Klymchenko, Andrey and Pivovarenko, Vasyl and Buchner, Markus and Muhr, Verena and Hirsch, Thomas and Mely, Yves (2017) Quantitative assessment of energy transfer in upconverting nanoparticles grafted with organic dyes. NANOSCALE, 9 (33). pp. 11994-12004. ISSN 2040-3364, 2040-3372
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Upconverting nanoparticles (UCNPs) are luminophores that have been investigated for a multitude of biological applications, notably low-background imaging, high-sensitivity assays, and cancer theranostics. In these applications, they are frequently used as a donor in resonance energy transfer (RET) pairs. However, because of the peculiarity and non-linearity of their luminescence mechanism, their behavior as a RET pair component has been difficult to predict quantitatively, preventing their optimization for subsequent applications. In this article, we assembled UCNP-organic dye RET systems and investigated their luminescence decays and spectra, with varying UCNP sizes and quantities of dyes grafted onto their surface. We observed an increase in RET efficiency with lower particle sizes and higher dye decoration. We also observed several unexpected effects, notably a quenching of UCNP luminescence bands that are not resonant with the absorption of organic dyes. We proposed a semi-empirical Monte Carlo model for predicting the behavior of UCNP-organic dye systems, and validated it by comparison with our experimental data. These findings will be useful for the development of more accurate UCNP-based assays, sensors, and imaging agents, as well as for optimization of UCNP-organic dye RET systems employed in cancer treatment and theranostics.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | UP-CONVERSION NANOPARTICLES; EXCITATION POWER; TRANSFER BIOSENSOR; DRUG-DELIVERY; LUMINESCENCE; NANOCRYSTALS; DESIGN; NANOSTRUCTURE; EFFICIENCY; PLATFORM; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 26 Feb 2019 08:33 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1191 |
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