Stadler, Stefan and Zimmermann, Tanja and Franke, Franziska and Rheinberger, Myriam and Heid, Iris M. and Boeger, Carsten A. and Arzt, Michael (2017) Association of sleep-disordered breathing with diabetes-associated kidney disease. ANNALS OF MEDICINE, 49 (6). pp. 487-495. ISSN 0785-3890, 1365-2060
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Introduction: Diabetes-associated kidney disease is characterized by impairment of renal function and albuminuria. The aim of the present study was to assess whether sleep-disordered breathing is associated with decreased estimated glomerular filtration rate or increased urine-albumin- to-creatinine-ratio independently from known modulators of diabetes-associated kidney disease. Material and methods: Estimated glomerular filtration rate and urine-albumin-to-creatinine-ratio were determined in the baseline survey of the DIACORE-SDB substudy, a prospectively planned study of Diabetes mellitus 2 patients. As a measure of the severity of sleep-disordered breathing, the apnea-hypopnea-index was assessed using a 2-channel ambulatory SDB-monitoring device. Results: A total of 679 patients (mean age 66 years, men 61%, mean body-mass-index 31.2 kg/m(2)) were analyzed. In multivariable linear regression models adjusting for known modulators of diabetes-associated kidney disease, such as sex, age, body-mass-index, systolic blood pressure, duration of diabetes and HbA1c, apnea-hypopnea-index [beta-estimate -0.2 ml/min/1.73 m(2), 95% CI (-0.3; -0.1), p = .004], duration of diabetes and age were associated with estimated glomerular filtration rate. Apnea-hypopnea-index [beta-estimate 0.01mg/g, 95% CI (0.00; 0.02), p = .009], duration of diabetes, HbA1c and systolic blood pressure were associated with ln(urine-albumin-to-creatinine-ratio). Conclusion: In patients with diabetes mellitus type 2, more severe sleep-disordered breathing is significantly associated with lower estimated glomerular filtration rate and increased albuminuria, independent of known modulators of diabetes-associated kidney disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | POSITIVE AIRWAY PRESSURE; APNEA SYNDROME; INTERMITTENT HYPOXIA; OXIDATIVE STRESS; RECORDING DEVICE; BLOOD-PRESSURE; RENAL-FAILURE; TYPE-2; NEPHROPATHY; PREVALENCE; Diabetes mellitus; kidney disease; sleep-disordered breathing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 12:57 |
| Last Modified: | 19 Feb 2019 14:20 |
| URI: | https://pred.uni-regensburg.de/id/eprint/12 |
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