de Rie, Derek and Abugessaisa, Imad and Alam, Tanvir and Arner, Erik and Arner, Peter and Ashoor, Haitham and Astrom, Gaby and Babina, Magda and Bertin, Nicolas and Burroughs, A. Maxwell and Carlisle, Ailsa J. and Daub, Carsten O. and Detmar, Michael and Deviatiiarov, Ruslan and Fort, Alexandre and Gebhard, Claudia and Goldowitz, Daniel and Guhl, Sven and Ha, Thomas J. and Harshbarger, Jayson and Hasegawa, Akira and Hashimoto, Kosuke and Herlyn, Meenhard and Heutink, Peter and Hitchens, Kelly J. and Hon, Chung Chau and Huang, Edward and Ishizu, Yuri and Kai, Chieko and Kasukawa, Takeya and Klinken, Peter and Lassmann, Timo and Lecellier, Charles-Henri and Lee, Weonju and Lizio, Marina and Makeev, Vsevolod and Mathelier, Anthony and Medvedeva, Yulia A. and Mejhert, Niklas and Mungall, Christopher J. and Noma, Shohei and Ohshima, Mitsuhiro and Okada-Hatakeyama, Mariko and Persson, Helena and Rizzu, Patrizia and Roudnicky, Filip and Saetrom, Pal and Sato, Hiroki and Severin, Jessica and Shin, Jay W. and Swoboda, Rolf K. and Tarui, Hiroshi and Toyoda, Hiroo and Vitting-Seerup, Kristoffer and Winteringham, Louise and Yamaguchi, Yoko and Yasuzawa, Kayoko and Yoneda, Misako and Yumoto, Noriko and Zabierowski, Susan and Zhang, Peter G. and Wells, Christine A. and Summers, Kim M. and Kawaji, Hideya and Sandelin, Albin and Rehli, Michael and Hayashizaki, Yoshihide and Carninci, Piero and Forrest, Alistair R. R. and de Hoon, Michiel J. L. (2017) An integrated expression atlas of miRNAs and their promoters in human and mouse. NATURE BIOTECHNOLOGY, 35 (9). 872-+. ISSN 1087-0156, 1546-1696
Full text not available from this repository. (Request a copy)Abstract
MicroRNAs (miRNAs) are short non-coding RNAs with key roles in cellular regulation. As part of the fifth edition of the Functional Annotation of Mammalian Genome (FANTOM5) project, we created an integrated expression atlas of miRNAs and their promoters by deep-sequencing 492 short RNA (sRNA) libraries, with matching Cap Analysis Gene Expression (CAGE) data, from 396 human and 47 mouse RNA samples. Promoters were identified for 1,357 human and 804 mouse miRNAs and showed strong sequence conservation between species. We also found that primary and mature miRNA expression levels were correlated, allowing us to use the primary miRNA measurements as a proxy for mature miRNA levels in a total of 1,829 human and 1,029 mouse CAGE libraries. We thus provide a broad atlas of miRNA expression and promoters in primary mammalian cells, establishing a foundation for detailed analysis of miRNA expression patterns and transcriptional control regions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENE-EXPRESSION; MICRORNA BIOGENESIS; SEQUENCING DATA; REGULATORY SITES; NONCODING RNAS; CAP-ANALYSIS; START SITES; TRANSCRIPTION; GENOME; CANCER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 25 Feb 2019 13:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1299 |
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