Bittner, Sebastian and Ehrenschwender, Martin (2017) Multifaceted death receptor 3 signaling-promoting survival and triggering death. FEBS LETTERS, 591 (17). pp. 2543-2555. ISSN 1873-3468
Full text not available from this repository. (Request a copy)Abstract
Death Receptor 3 (DR3) and its cognate ligand TL1A belong to the tumor necrosis factor superfamily (TNFSF). This sophisticated network of receptor-ligand systems controls innumerable biological processes. For many (if not all) TNFSF ligands and receptors, a role in conditions such as inflammation, tissue development, proliferation, and cell death has been firmly established. However, relatively little is known about DR3 and TL1A. Here, we review novel aspects of DR3 signaling and DR3-associated signaling pathways before summarizing the function of DR3 in the immune system. The emerging role of DR3 in disease will be addressed before we finally critically discuss the potential therapeutic exploitation of this receptor-ligand pair.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TNF-LIKE LIGAND; INFLAMMATORY-BOWEL-DISEASE; REGULATORY T-CELLS; VERSUS-HOST-DISEASE; DOMAIN-CONTAINING RECEPTOR; INNATE LYMPHOID-CELLS; SINGLE NUCLEOTIDE POLYMORPHISMS; ALLERGIC LUNG INFLAMMATION; PRIMARY BILIARY-CIRRHOSIS; GENOME-WIDE ASSOCIATION; DR3; TL1A; TNFRSF25 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 17 Sep 2020 07:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1303 |
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