Simeth, Nadja A. and Kneuttinger, Andrea C. and Sterner, Reinhard and Koenig, Burkhard (2017) Photochromic coenzyme Q derivatives: switching redox potentials with light. CHEMICAL SCIENCE, 8 (9). pp. 6474-6483. ISSN 2041-6520, 2041-6539
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Coenzyme Q is an important redox cofactor involved in a variety of cellular processes, and is thus found in several cell compartments. We report a photochromic derivative of coenzyme Q that combines the molecular structures of the redox active cofactor and a photochromic dye. Light irradiation triggers an electronic rearrangement reversibly changing the redox potential. We used this effect to control the intermolecular redox reaction of the photochromic coenzyme Q derivative with dihydropyridine in solution by light irradiation. On mitochondria, the altered redox properties showed an effect on the respiratory chain. The experiments demonstrate that the redox reactions can be initiated inside the system of interest through irradiation with light and the accompanied photoisomerization.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | OPTICAL CONTROL; P-BENZOQUINONE; INHIBITORS; DIARYLETHENE; REDUCTION; DENSITY; PROTEIN; PHOTOPHARMACOLOGY; UBIQUINONE; CONVERSION; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 26 Feb 2019 08:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1323 |
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