Tabenski, Laura and Moder, Daniel and Cieplik, Fabian and Schenke, Frederike and Hiller, Karl-Anton and Buchalla, Wolfgang and Schmalz, Gottfried and Christgau, Michael (2017) Antimicrobial photodynamic therapy vs. local minocycline in addition to non-surgical therapy of deep periodontal pockets: a controlled randomized clinical trial. CLINICAL ORAL INVESTIGATIONS, 21 (7). pp. 2253-2264. ISSN 1432-6981, 1436-3771
Full text not available from this repository. (Request a copy)Abstract
To investigate the additional influence of either antimicrobial photodynamic therapy (aPDT; HelboA (R) Photodynamic Systems) or local application of minocycline microspheres (MC; Arestin, OraPharma) on clinical and microbiological healing results in deep periodontal pockets (PPD ae<yen>6 mm) following non-surgical periodontal therapy (SRP). Forty-five patients with chronic periodontitis were evaluated: test group aPDT + SRP (n = 15), positive control group MC + SRP (n = 15), and negative control group SRP-alone (n = 15). Clinical and microbiological healing parameters were recorded in every patient for four experimental teeth at baseline, 6 weeks, and 3, 6, and 12 months. Wilcoxon signed-rank test and Mann-Whitney U test were used for statistical analysis (alpha = 0.05). Significant improvements in clinical and microbiological parameters were found for all groups after 6 weeks and 3, 6, and 12 months. Differences between groups were not statistically significant. Changes after 12 months [median (25/75%)] are as follows: reduction in PPD [mm]: aPDT + SRP 2 (1/3), MC + SRP 3 (1/4), SRP-alone 2 (1/3); percentage of residual BOP positive teeth [%]: aPDT + SRP 75 (25/100), MC + SRP 33.3 (0/50), SRP-alone 66.7 (25/75). Within the limitations of this study, neither the applied aPDT system nor MC showed a significant additional influence on clinical and microbiological healing outcomes in deep periodontal pockets compared to SRP alone. In deep periodontal defects, the efficacy of non-surgical periodontal treatment seems not to be improved by adjunctive use of antimicrobial photodynamic therapy or minocycline microspheres.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GENERALIZED AGGRESSIVE PERIODONTITIS; METRONIDAZOLE PLUS AMOXICILLIN; IMPLEMENTED TREATMENT STRATEGY; DRUG DELIVERY; POVIDONE-IODINE; ADJUNCT; DEBRIDEMENT; AZITHROMYCIN; INFECTIONS; DISEASES; Antimicrobial photodynamic therapy; Non-surgical periodontal therapy; Minocycline; Local antibiotics; Scaling and root planing |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Zahnerhaltung und Parodontologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 18 Feb 2019 14:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1335 |
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