Blume, Josefine and Schlaier, J. and Rothenfusser, E. and Anthofer, J. and Zeman, F. and Brawanski, A. and Bogdahn, U. and Lange, M. (2017) Intraoperative clinical testing overestimates the therapeutic window of the permanent DBS electrode in the subthalamic nucleus. ACTA NEUROCHIRURGICA, 159 (9). pp. 1721-1726. ISSN 0001-6268, 0942-0940
Full text not available from this repository. (Request a copy)Abstract
Intraoperative test stimulation is established to optimize target localization in STN DBS, but requires a time-consuming awake surgery in off-medication state. The aim of this study was to compare the thresholds of stimulation-induced effects of test stimulation and the permanent electrode. Fifty-nine PD patients receiving bilateral STN DBS were clinically examined with stepwise increasing monopolar stimulation during surgery and DBS programming at matched stimulation depths. Thresholds of therapeutic and side effects were obtained from standardized examination protocols. Postoperative stimulation via the permanent electrode caused side effects at a significantly lower threshold than predicted during intraoperative test stimulation (P < 0.001); whereas sufficient therapeutic effects were achieved at significantly higher thresholds (P < 0.001). Intraoperative testing may lead to an overestimation of the therapeutic window. The two different electrodes lead to distinct spreading of the electric field in the STN and surrounding tissues that causes different volume of tissue activated (VTA). Clinicians involved in DBS surgery and programming should be aware of the differences in both stimulation settings, concerning electrodes geometry, stimulation modes as well as the impact of time. Therapeutic and side effects of permanent stimulation are not predictable by intraoperative test stimulation. Test stimulation may be an orientating test for very low thresholds of side effects instead.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DEEP-BRAIN-STIMULATION; PARKINSONS-DISEASE; MRI; LOCATION; DESIGN; VOLUME; STN; GPI; Deep brain stimulation; Subthalamic nucleus; Parkinson; Stimulation-induced side effects; Intraoperative clinical testing; Microelectrode recording |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 18 Feb 2019 14:42 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1336 |
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