Pena-Solorzano, Diana and Stark, Simone Alexandra and Koenig, Burkhard and Augusto Sierra, Cesar and Ochoa-Puentes, Cristian (2017) ABCG2/BCRP: Specific and Nonspecific Modulators. MEDICINAL RESEARCH REVIEWS, 37 (5). pp. 987-1050. ISSN 0198-6325, 1098-1128
Full text not available from this repository. (Request a copy)Abstract
Multidrug resistance (MDR) in cancer cells is the development of resistance to a variety of structurally and functionally nonrelated anticancer drugs. This phenomenon has become a major obstacle to cancer chemotherapy seriously affecting the clinical outcome. MDR is associated with increased drug efflux from cells mediated by an energy-dependent mechanism involving the ATP-binding cassette (ABC) transporters, mainly P-glycoprotein (ABCB1), the MDR-associated protein-1 (ABCC1), and the breast cancer resistance protein (ABCG2). The first two transporters have been widely studied already and reviews summarized the results. The ABCG2 protein has been a subject of intense study since its discovery as its overexpression has been detected in resistant cell lines in numerous types of human cancers. To date, a long list of modulators of ABCG2 exists and continues to increase. However, little is known about the clinical consequences of ABCG2 modulation. This makes the design of novel, potent, and nontoxic inhibitors of this efflux protein a major challenge to reverse MDR and thereby increase the success of chemotherapy. The aim of the present review is to describe and highlight specific and nonspecific modulators of ABCG2 reported to date based on the selectivity of the compounds, as many of them are effective against one or more ABC transport proteins. (C) 2016 Wiley Periodicals, Inc. Med. Res. Rev., 37, No. 5, 987-1050, 2017
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CANCER RESISTANCE PROTEIN; P-GLYCOPROTEIN ABCB1; REVERSES MULTIDRUG-RESISTANCE; TYROSINE KINASE INHIBITOR; MEDIATED DRUG-RESISTANCE; TRANSPORTER IN-VITRO; STEM-LIKE CELLS; G MEMBER 2; MARINE NATURAL-PRODUCTS; SELECTIVE INHIBITORS; ABC transporter; ABCG2/BCRP; multidrug resistance; ABC inhibitor; ABC modulator |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:15 |
| Last Modified: | 13 Feb 2019 08:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1348 |
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