Dmitriev, Olga A. and Fedotova, Marina V. and Buchner, Richard (2017) Evidence for cooperative Na+ and Cl- binding by strongly hydrated L-proline. PHYSICAL CHEMISTRY CHEMICAL PHYSICS, 19 (31). pp. 20474-20483. ISSN 1463-9076, 1463-9084
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In nature the amino acid L-proline (Pro) is a ubiquitous and highly effective osmolyte protecting cells against osmotic stress. To understand this effect knowledge of the hydration of Pro and its interactions with dissolved salts is essential. We studied these properties by combining statistical mechanics and broadband dielectric spectroscopy and found that Pro remains strongly hydrated up to high amino-acid concentrations. This is also the case upon NaCl addition to a 0.6 M Pro solution. Here, additionally a Pro center dot NaCl aggregate is formed with a stability constant of K degrees approximate to 0.95...1.25 M-1, where Na+ and Cl- cooperatively bind to adjacent carboxylate-oxygen and ammonium-hydrogen atoms, respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DIELECTRIC-RELAXATION SPECTROSCOPY; MOLECULAR-DYNAMICS SIMULATIONS; RELEVANT INORGANIC-IONS; INTERACTION SITE MODEL; ELECTROLYTE-SOLUTIONS; AQUEOUS PROLINE; AMINO-ACIDS; WATER; AGGREGATION; ZWITTERION; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > PD Dr. Richard Buchner |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 26 Feb 2019 08:56 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1375 |
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