Melnik, Bodo C. and Schmitz, Gerd (2017) MicroRNAs: Milk's epigenetic regulators. BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 31 (4). pp. 427-442. ISSN 1521-690X, 1532-1908
Full text not available from this repository. (Request a copy)Abstract
Our perception of milk has changed from a "simple food" to a highly sophisticated maternal neonatal nutrient and communication system orchestrating early programming of the infant. Milk miRNAs delivered by exosomes and milk fat globules derived from mammary gland epithelial cells play a key role in this process. Exosomes resist the harsh intestinal environment, are taken up by intestinal cells via endocytosis, and reach the systemic circulation of the milk recipient. The most abundant miRNA found in exosomes and milk fat globules of human and cow's milk, miRNA-148a, attenuates the expression of DNA methyltransferase 1, which is critically involved in epigenetic regulation. Another important miRNA of milk, miRNA-125b, targets p53, the guardian of the genome, and its diverse transcriptional network. The deficiency of exosomal miRNAs in infant formula and the persistent uptake of milk miRNAs after the nursing period via consumption of cow's milk are two epigenetic aberrations that may induce adverse long-term effects on human health. (C) 2017 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNE-RELATED MICRORNAS; GENE-EXPRESSION; BREAST-MILK; DNA METHYLATION; MESSENGER-RNA; INTERCELLULAR COMMUNICATION; EXTRACELLULAR VESICLES; BIRTH-WEIGHT; FOOD-INTAKE; COWS MILK; epigenetic regulation; DNA methyltransferase 1; formula; milk; miRNA-148a; p53 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 15 Feb 2019 08:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1401 |
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