Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation

Reinders, Yvonne and Felthaus, Oliver and Brockhoff, Gero and Pohl, Fabian and Ahrens, Norbert and Prantl, Lukas and Haubner, Frank (2017) Impact of Platelet-Rich Plasma on Viability and Proliferation in Wound Healing Processes after External Radiation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 18 (8): 1819. ISSN 1422-0067,

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Abstract

Platelet-rich plasma is a current subject of studies on chronic wound healing therapy due to possible pro-angiogenic effects. Microvascular compromise represents the major component in radiogenic wound healing complications. The effects of platelet-rich plasma on irradiated cells of the cutaneous wound healing process are poorly understood so far. In this study, the interaction of endothelial cells and adipose-derived stem cells in conjunction with treatment with platelet-rich plasma is investigated in the context of radiation effects. Therefore, the expression of surface-marker CD90 and CD31 was determined. Moreover, cell proliferation and viability after external radiation was analyzed with and without treatment by platelet-rich plasma.

Item Type: Article
Uncontrolled Keywords: STEM-CELLS; GROWTH; DIFFERENTIATION; REGENERATION; RADIOTHERAPY; FIBRIN; MODEL; TRIAL; GEL; radiation therapy; human adipose-derived stem cells; microvascular endothelial cells; platelet-rich plasma
Subjects: 600 Technology > 610 Medical sciences Medicine
Divisions: Medicine > Lehrstuhl für Chirurgie
Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde)
Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Medicine > Lehrstuhl für Strahlentherapie
Depositing User: Dr. Gernot Deinzer
Date Deposited: 14 Dec 2018 13:16
Last Modified: 28 Feb 2019 10:53
URI: https://pred.uni-regensburg.de/id/eprint/1412

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