Hutterer, Markus and Ebner, Yvonne and Riemenschneider, Markus J. and Willuweit, Antje and McCoy, Mark and Egger, Barbara and Schroeder, Michael and Wendl, Christina and Hellwig, Dirk and Grosse, Jirka and Menhart, Karin and Proescholdt, Martin and Fritsch, Brita and Urbach, Horst and Stockhammer, Guenther and Roelcke, Ulrich and Galldiks, Norbert and Meyer, Philipp T. and Langen, Karl-Josef and Hau, Peter and Trinka, Eugen (2017) Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by F-18-Fluoroethyl-L-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic. JOURNAL OF NUCLEAR MEDICINE, 58 (1). pp. 129-137. ISSN 0161-5505, 1535-5667
Full text not available from this repository. (Request a copy)Abstract
O-(2-F-18-fluoroethyl)-L-tyrosine (F-18-FET) PET is a well-established method increasingly used for diagnosis, treatment planning, and monitoring in gliomas. Epileptic activity, frequently occurring in glioma patients, can influence MRI findings. Whether seizures also affect F-18-FET PET imaging is currently unknown. The aim of this retrospective analysis was to investigate the brain amino acid metabolism during epileptic seizures by F-18-FET PET and to elucidate the pathophysiologic background. Methods: Ten patients with 11 episodes of serial seizures or status epilepticus, who underwent MRI and F-18-FET PET, were studied. The main diagnosis was glioma World Health Organization grade II-1V (n = 8); 2 patients suffered from nonneoplastic diseases. Immunohistochemical assessment of LAT1/ LAT2/CD98 amino acid transporters was performed in seizure-affected cortex (n = 2) and compared with glioma tissues (n = 3). Results: All patients exhibited increased seizure-associated strict gyral F-18-FET uptake, which was reversible in follow-up studies or negative shortly before and without any histologic or clinical signs of tumor recurrence. F-18-FET uptake corresponded to structural MRI changes, compatible with cortical vasogenic and cytotoxic edema, partial contrast enhancement, and hyperperfusion. Patients with prolonged postictal symptoms lasting up to 8 wk displayed intensive and widespread 1 lobe) cortical F-18-FET uptake. LAT1/LAT2/CD98 was strongly expressed in neurons and endothelium of seizure-affected brains and less in reactive astrocytosis. Conclusion: Seizure activity, in particular status epilepticus, increases cerebral amino acid transport with a strict gyral F-18-FET uptake pattern. Such periictal pseudoprogression represents a potential pitfall of F-18-FET PET and may mimic brain tumor. Our data also indicate a seizure-induced upregulation of neuronal, endothelial, and less astroglial LAT1/LAT2/CD98 amino acid transporter expression.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NONCONVULSIVE STATUS EPILEPTICUS; POSITRON-EMISSION-TOMOGRAPHY; DIFFERENTIAL UPTAKE; CORTICAL DYSPLASIA; F-18-FET PET; MANAGEMENT; GLIOMA; MECHANISMS; CHILDREN; SPECT; epileptic seizure; status epilepticus; F-18-FET PET; glioma; LAT1/2 expression |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Abteilung für Neuropathologie Medicine > Lehrstuhl für Röntgendiagnostik Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 12:58 |
| Last Modified: | 25 Feb 2019 14:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/143 |
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