Gregoritza, Manuel and Messmann, Viktoria and Abstiens, Kathrin and Brandl, Ferdinand P. and Goepferich, Achim M. (2017) Controlled Antibody Release from Degradable Thermoresponsive Hydrogels Cross-Linked by Diets-Alder Chemistry. BIOMACROMOLECULES, 18 (8). pp. 2410-2418. ISSN 1525-7797, 1526-4602
Full text not available from this repository. (Request a copy)Abstract
Amine-modified four- and eight-armed poloxamines were prepared and subsequently functionalized with maleimide or fury' groups. Aqueous solutions of these polymers exhibited an immediate gelation at a temperature above 37 C. Concomitantly, Diets Alder reactions gradually cross-linked and cured the gels. Different ratios between four- and eight-armed macromonomers were used to tune hydrogel stability and mechanical properties. In this way, hydrogel stability could be precisely controlled in the range of 14 to 329 days. Controlled release of the model antibody bevacizumab was achieved over a period of 7, 21, and 115 days. Release profiles were triphasic with a low burst; approximately 87% of the released antibody was intact and displayed functional binding. The hydrogels presented in this study are degradable, nontoxic, rapidly gelling, stable, and provide controlled antibody release. They can be tailored to match the demands of various applications and present an attractive platform for antibody delivery.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SITU-FORMING HYDROGELS; THERMAL GELATION; RESPONSIVE POLYMERS; DRUG-DELIVERY; PROTEIN; LINKING; STABILITY; SYSTEMS; TANDEM; FORMULATION; |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 20 Feb 2019 07:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1443 |
Actions (login required)
 |
View Item |
