Camboni, Daniele and Philipp, Alois and Rottenkolber, Verena and Zerdzitzki, Matthaeus and Holzamer, Andreas and Floerchinger, Bernhard and Lunz, Dirk and Mueller, Thomas and Schmid, Christof and Diez, Claudius (2017) Long-term survival and quality of life after extracorporeal life support: a 10-year report. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 52 (2). pp. 241-247. ISSN 1010-7940, 1873-734X
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OBJECTIVES: Information is lacking about long-term survival and quality of life (QOL) after treating patients on extracorporeal life support. METHODS: Outcome data were assessed by phone interviews, a QOL analysis using the EuroQol 5-dimensions questionnaire and a retrospective inquiry of the Regensburg ECMO Registry database for the decade 2006-2015. A statistical analysis was obtained by comparing patients with a cardiosurgical intervention (CS = 189 patients) with those without (w/oCS = 307 patients). RESULTS: Survival to discharge in the w/oCS group was higher than that in the CS group (w/oCS: 41.7% vs CS: 29.5%; P = 0.004). A Kaplan-Meier analysis showed a significant difference between both groups in favour of patients w/oCS (log rank P = 0.02). This difference was no longer statistically significant after propensity score matching (P = 0.07). The 1- and 2-year survival rates of discharged patients were 67% and 50% in the w/oCS group vs 60% and 45% in the CS group (log rank P = 0.29). Eighty-two patients answered the QOL questionnaire after a mean follow-up time of 4.2 +/- 2.9 years. A total of 75% could handle their daily life; 57% were not limited in their usual activities. Mobility impairment was noted in 50%; 25% returned to work or school. There were no differences in the EuroQol 5-dimension indices between the patient groups. However, compared to a normative age-matched population, significantly lower indices were calculated. CONCLUSIONS: Long-term survival rates in patients requiring extracorporeal life support are acceptable with a probable advantage for patients without an operation and a narrowed QOL. The results are promising and encouraging, but there is also a need for improvement.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MEMBRANE-OXYGENATION; CARDIOGENIC-SHOCK; OUTCOMES; ADULTS; TRENDS; EQ-5D; ECMO; Extracorporeal life support; Outcome; Quality-of-life |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Herz-, Thorax- und herznahe Gefäßchirurgie Medicine > Lehrstuhl für Innere Medizin II |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 20 Feb 2019 15:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1447 |
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