Grebler, Rudi and Kistenpfennig, Christa and Rieger, Dirk and Bentrop, Joachim and Schneuwly, Stephan and Senthilan, Pingkalai R. and Helfrich-Foerster, Charlotte (2017) Drosophila Rhodopsin 7 can partially replace the structural role of Rhodopsin 1, but not its physiological function. JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY, 203 (8). pp. 649-659. ISSN 0340-7594, 1432-1351
Full text not available from this repository. (Request a copy)Abstract
Rhodopsin 7 (Rh7), a new invertebrate Rhodopsin gene, was discovered in the genome of Drosophila melanogaster in 2000 and thought to encode for a functional Rhodopsin protein. Indeed, Rh7 exhibits most hallmarks of the known Rhodopsins, except for the G-protein-activating QAKK motif in the third cytoplasmic loop that is absent in Rh7. Here, we show that Rh7 can partially substitute Rh1 in the outer receptor cells (R1-6) for rhabdomere maintenance, but that it cannot activate the phototransduction cascade in these cells. This speaks against a role of Rh7 as photopigment in R1-6, but does not exclude that it works in the inner photoreceptor cells.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | RETINAL DEGENERATION; COMPOUND EYE; HETEROLOGOUS EXPRESSION; PHOTORECEPTOR CELLS; ECTOPIC EXPRESSION; MELANOGASTER; OPSIN; GENE; SYSTEM; BLUE; Phototransduction; Electroretinograms; Rhodopsins; Compound eyes; Drosophila melanogaster |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Entwicklungsbiologie (Prof. Dr. Stephan Schneuwly) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 18 Feb 2019 14:51 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1466 |
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