Karremann, Michael and Kraemer, Nadja and Hoffmann, Marion and Wiese, Maria and Beilken, Andreas and Corbacioglu, Selim and Dilloo, Dagmar and Driever, Pablo Hernaiz and Scheurlen, Wolfram and Kulozik, Andreas and Gielen, Gerrit H. and von Bueren, Andre O. and Duerken, Matthias and Kramm, Christof M. (2017) Haematological malignancies following temozolomide treatment for paediatric high-grade glioma. EUROPEAN JOURNAL OF CANCER, 81. pp. 1-8. ISSN 0959-8049, 1879-0852
Full text not available from this repository. (Request a copy)Abstract
Background: Temozolomide (TMZ) is widely used in high-grade glioma (HGG). There is a major concern of treatment-induced secondary haematological malignancies (SHMs). Due to the poor overall survival of HGG patients, the true incidence is yet elusive. Thus, the aim of this study was to determine the risk of SHMs following TMZ in paediatric HGG. Methods: We analysed 487 patients from the HIT-HGG database of the German-speaking Society of Pediatric Oncology and Hematology with follow up beyond 1 year. Results: The incidence of SHM was 7.7 +/- 3.2% at 10 years. No SHM occurred in 194 patients after first-line TMZ therapy, but four out of 131 patients treated with TMZ for relapse following first-line multiagent chemotherapy experienced SHM (20% at 10 years; p = 0.041). SHMs occurred in two out of 162 patients who underwent multiagent chemotherapy without TMZ (4.1% at 10 years). Gender, patient age and acute haematological toxicity during treatment did not affect the incidence of SHMs. Conclusion: Data of our cohort do not indicate an increased risk of SHM following TMZ treatment when compared to previous chemotherapy regimen. However, if TMZ is administered as a second-line treatment following conventional chemotherapy regimen, the risk might be disproportionately increasing. (C) 2017 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CENTRAL-NERVOUS-SYSTEM; MYELODYSPLASTIC SYNDROME; IMPROVES SURVIVAL; GLIOBLASTOMA; CHEMOTHERAPY; SECONDARY; THERAPY; TUMORS; Children; Glioblastoma; High-grade glioma; Secondary haematological malignancies |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 15 Feb 2019 08:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1506 |
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