Onder, Lucas and Moerbe, Urs and Pikor, Natalia and Novkovic, Mario and Cheng, Hung-Wei and Hehlgans, Thomas and Pfeffer, Klaus and Becher, Burkhard and Waisman, Ari and Ruelicke, Thomas and Gommerman, Jennifer and Mueller, Christopher G. and Sawa, Shinichiro and Scandella, Elke and Ludewig, Burkhard (2017) Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis. IMMUNITY, 47 (1). 80-+. ISSN 1074-7613, 1097-4180
Full text not available from this repository. (Request a copy)Abstract
Lymph nodes (LNs) are strategically situated throughout the body at junctures of the blood vascular and lymphatic systems to direct immune responses against antigens draining from peripheral tissues. The current paradigm describes LN development as a programmed process that is governed through the interaction between mesenchymal lymphoid tissue organizer (LTo) cells and hematopoietic lymphoid tissue inducer (LTi) cells. Using cell-type-specific ablation of key molecules involved in lymphoid organogenesis, we found that initiation of LN development is dependent on LTi-cell-mediated activation of lymphatic endothelial cells (LECs) and that engagement of mesenchymal stromal cells is a succeeding event. LEC activation was mediated mainly by signaling through receptor activator of NF-kappa B (RANK) and the non-canonical NF-kappa B pathway and was steered by sphingosine-1-phosphate-receptor-dependent retention of LTi cells in the LN anlage. Finally, the finding that pharmacologically enforced interaction between LTi cells and LECs promotes ectopic LN formation underscores the central LTo function of LECs.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LYMPHOTOXIN-BETA-RECEPTOR; NF-KAPPA-B; TUMOR-NECROSIS-FACTOR; PEYERS PATCH ORGANOGENESIS; T-CELLS; STROMAL CELLS; ORGANS; MICE; TISSUES; MACROPHAGES; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Regensburger Centrum für Interventionelle Immunologie (RCI) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 28 Feb 2019 12:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1533 |
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