Munker, Stefan and Wu, Yong-Le and Ding, Hui-Guo and Liebe, Roman and Weng, Hong-Lei (2017) Can a fibrotic liver afford epithelial-mesenchymal transition? WORLD JOURNAL OF GASTROENTEROLOGY, 23 (26). pp. 4661-4668. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
The question whether epithelial-mesenchymal transition (EMT) occurs during liver fibrogenesis is a controversial issue. In vitro studies confirm that hepatocytes or cholangiocytes undergo EMT upon transforming growth factor beta (TGF-beta) stimulation, whereas in vivo experiments based on genetic fate mapping of specific cell populations suggest that EMT does not occur in fibrotic animal models. In this review we present current data supporting or opposing EMT in chronic liver disease and discuss conditions for the occurrence of EMT in patients. Based on the available data and our clinical observations we hypothesize that EMT-like alterations in liver cirrhosis are a side effect of high levels of TGF-beta and other pro-fibrotic mediators rather than a biological process converting functional parenchyma, i.e., hepatocytes, into myofibroblasts at a time when essential liver functions are deteriorating.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-BETA; TGF-BETA; PARENCHYMAL EXTINCTION; MOLECULAR-MECHANISMS; INDUCED APOPTOSIS; HUMAN CIRRHOSIS; STELLATE CELL; ADULT LIVER; FIBROSIS; HEPATOCYTES; Epithelial-mesenchymal transition; Liver fibrosis; Liver cirrhosis; Transforming growth factor-beta |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 01 Mar 2019 07:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1543 |
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