Brenna, Davide and Villa, Matteo and Gieshoff, Tim N. and Fischer, Fabian and Hapke, Marko and Jacobi von Wangelin, Axel (2017) Iron-Catalyzed Cyclotrimerization of Terminal Alkynes by Dual Catalyst Activation in the Absence of Reductants. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56 (29). pp. 8451-8454. ISSN 1433-7851, 1521-3773
Full text not available from this repository. (Request a copy)Abstract
Catalyzing C-C bond-forming reactions with earth-abundant metals under mild conditions is at the heart of sustainable synthesis. The cyclotrimerization of alkynes is a valuable atom-efficient reaction in organic synthesis that is enabled by several metal catalysts, including iron. This study reports an effective iron-catalyzed cyclotrimerization for the regioselective synthesis of 1,2,4-substituted arenes (1 mol% catalyst, toluene, 20 degrees C, 5 min). A dual activation mechanism (substrate deprotonation, reductive elimination) renders the simple Fe-II precatalyst highly active in the absence of any reductant.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 2+2+2 CYCLOADDITION; INTRAMOLECULAR CYCLOTRIMERIZATION; HETEROGENEOUS CATALYSIS; ORGANIC-SYNTHESIS; COMPLEXES; DIYNES; METAL; HYDROGENATIONS; TRIYNES; alkynes; arene synthesis; cyclotrimerization; iron; nanoparticles |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Arbeitskreis Prof. Dr. Axel Jacobi von Wangelin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 11 Feb 2019 14:39 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1548 |
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