Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy

Kalbitzer, Hans Robert and Rosnizeck, Ina C. and Munte, Claudia E. and Narayanan, Sunilkumar Puthenpurackal and Kropf, Veronika and Spoerner, Michael (2013) Intrinsic Allosteric Inhibition of Signaling Proteins by Targeting Rare Interaction States Detected by High-Pressure NMR Spectroscopy. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 52 (52). pp. 14242-14246. ISSN 1433-7851, 1521-3773

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Item Type: Article
Uncontrolled Keywords: RAS-BINDING DOMAIN; EFFECTOR; TRANSITIONS; COMPLEXES; MECHANISM; allosteric inhibition; conformational states; drug design; high-pressure NMR spectroscopy; Ras protein
Subjects: 500 Science > 570 Life sciences
Divisions: Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie
Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Dr. Hans Robert Kalbitzer
Depositing User: Dr. Gernot Deinzer
Date Deposited: 23 Mar 2020 07:04
Last Modified: 23 Mar 2020 07:04
URI: https://pred.uni-regensburg.de/id/eprint/15508

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