Boehm, Matthias and Faltermeier, Rupert and Brawanski, Alexander and Lang, Elmar W. (2013) Mathematical modeling of human brain physiological data. PHYSICAL REVIEW E, 88 (6): 062711. ISSN 2470-0045, 2470-0053
Full text not available from this repository. (Request a copy)Abstract
Recently, a mathematical model of the basic physiological processes regulating the cerebral perfusion and oxygen supply was introduced [Jung et al., J. Math. Biol. 51, 491 (2005)]. Although this model correctly describes the interdependence of arterial blood pressure (ABP) and intracranial pressure (ICP), it fails badly when it comes to explaining certain abnormal correlations seen in about 80% of the recordings of ABP together with ICP and the partial oxygen pressure (TiPO2) of the neuronal tissue, taken at an intensive care unit during neuromonitoring of patients with a severe brain trauma. Such recordings occasionally show segments, where the mean arterial blood pressure is correlated with the partial oxygen pressure in tissue but anticorrelated with the intracranial pressure. The origin of such abnormal correlations has not been fully understood yet. Here, two extensions to the previous approach are proposed which can reproduce such abnormal correlations in simulations quantitatively. Furthermore, as the simulations are based on a mathematical model, additional insight into the physiological mechanisms from which such abnormal correlations originate can be gained.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | INTRACRANIAL-PRESSURE DYNAMICS; CEREBRAL-BLOOD-FLOW; HYDRODYNAMICS; HEMODYNAMICS; SIMULATION; |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie Biology, Preclinical Medicine > Institut für Biophysik und physikalische Biochemie > Prof. Dr. Elmar Lang |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Mar 2020 08:00 |
| Last Modified: | 23 Mar 2020 08:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15529 |
Actions (login required)
 |
View Item |
