Hombach, Sonja and Kretz, Markus (2013) The non-coding skin: Exploring the roles of long non-coding RNAs in epidermal homeostasis and disease. BIOESSAYS, 35 (12). pp. 1093-1100. ISSN 0265-9247, 1521-1878
Full text not available from this repository. (Request a copy)Abstract
Long non-coding RNAs (lncRNAs) have recently gained increasing attention because of their crucial roles in gene regulatory processes. Functional studies using mammalian skin as a model system have revealed their role in controlling normal tissue homeostasis as well as the transition to a diseased state. Here, we describe how lncRNAs regulate differentiation to preserve an undifferentiated epidermal progenitor compartment, and to maintain a functional skin permeability barrier. Furthermore, we will reflect on recent work analyzing the impact of lncRNAs on the progression from normal epithelium to the development of skin disorders and cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | X-CHROMOSOME INACTIVATION; STEM-CELLS; GENE-EXPRESSION; DIFFERENTIATION; CHROMATIN; TRANSCRIPTION; PSORIASIS; CANCER; IDENTIFICATION; MECHANISMS; differentiation; epidermis; lncRNA; melanoma; non-coding RNA; skin |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Biochemie, Genetik und Mikrobiologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 19 Jun 2020 09:50 |
| Last Modified: | 19 Jun 2020 09:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15550 |
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