Keller, Till and Boeckel, Jes-Niels and Gross, Stefan and Klotsche, Jens and Palapies, Lars and Leistner, David and Pieper, Lars and Stalla, Guennter K. and Lehnert, Hendrik and Silber, Sigmund and Pittrow, David and Maerz, Winfried and Doerr, Marcus and Wittchen, Hans-Ulrich and Baumeister, Sebastian E. and Voelker, Uwe and Felix, Stephan B. and Dimmeler, Stefanie and Zeiher, Andreas M. (2017) Improved risk stratification in prevention by use of a panel of selected circulating microRNAs. SCIENTIFIC REPORTS, 7: 4511. ISSN 2045-2322,
Full text not available from this repository. (Request a copy)Abstract
Risk stratification is crucial in prevention. Circulating microRNAs have been proposed as biomarkers in cardiovascular disease. Here a miR panel consisting of miRs related to different cardiovascular pathophysiologies, was evaluated to predict outcome in the context of prevention. MiR-34a, miR-223, miR-378, miR-499 and miR-133 were determined from peripheral blood by qPCR and combined to a risk panel. As derivation cohort, 178 individuals of the DETECT study, and as validation cohort, 129 individuals of the SHIP study were used in a case-control approach. Overall mortality and cardiovascular events were outcome measures. The Framingham Risk Score(FRS) and the SCORE system were applied as risk classification systems. The identified miR panel was significantly associated with mortality given by a hazard ratio(HR) of 3.0 (95% (CI): 1.09-8.43; p = 0.034) and of 2.9 (95% CI: 1.32-6.33; p = 0.008) after adjusting for the FRS in the derivation cohort. In a validation cohort the miR-panel had a HR of 1.31 (95% CI: 1.03-1.66; p = 0.03) and of 1.29 (95% CI: 1.02-1.64; p = 0.03) in a FRS/SCORE adjusted-model. A FRS/SCORE risk model was significantly improved to predict mortality by the miR panel with continuous net reclassification index of 0.42/0.49 (p = 0.014/0.005). The present miR panel of 5 circulating miRs is able to improve risk stratification in prevention with respect to mortality beyond the FRS or SCORE.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE MYOCARDIAL-INFARCTION; C-REACTIVE PROTEIN; CARDIOVASCULAR-DISEASE; NONPARAMETRIC APPROACH; NATRIURETIC PEPTIDE; CARDIAC-HYPERTROPHY; SENSITIVE ASSAY; BIOMARKERS; PREDICTION; MORTALITY; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Institut für Epidemiologie und Präventivmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 14 Dec 2018 13:16 |
| Last Modified: | 25 Feb 2019 14:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/1560 |
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