Skrzypczak, Maciej and Lattrich, Claus and Haering, Julia and Schueler, Susanne and Ortmann, Olaf and Treeck, Oliver (2013) Expression of SCUBE2 gene declines in high grade endometrial cancer and associates with expression of steroid hormone receptors and tumor suppressor PTEN. GYNECOLOGICAL ENDOCRINOLOGY, 29 (12). pp. 1031-1035. ISSN 0951-3590, 1473-0766
Full text not available from this repository. (Request a copy)Abstract
SCUBE2 (Signal peptide-CUB-epidermal growth factor-like domain-containing 2) gene codes for a cell-surface glycoprotein. In breast cancer, SCUBE2 transcript levels are part of important prognostic and predictive gene signatures and are linked to expression of estrogen receptor a (ER alpha). To elucidate the role of this gene in endometrial cancer, we compared SCUBE2 expression in malignant and normal endometrial tissue specimens. We then examined its correlation with steroid hormone receptors and PTEN and compared it to SCUBE2 expression in breast cancer samples. Expression of SCUBE2 was found to be decreased in G3 endometrial cancer when compared to postmenopausal endometrium or to G1 tumors (p<0.05). In postmenopausal endometrium, SCUBE2 transcript levels were more than twice as high as in premenopausal women. In breast cancer, SCUBE2 expression was found to be notably reduced particularly in ER alpha-negative G3 tumors. Both in endometrial and breast cancer we observed a significant positive correlation of SCUBE2 transcript levels with expression of ER alpha, PR and PTEN. Our data suggest that SCUBE2, like in breast cancer, associates with ER alpha and might have a potential as prognostic or predictive marker in endometrial cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CELL-SURFACE GLYCOPROTEIN; BREAST-CANCER; CLINICAL-IMPLICATIONS; CARCINOMA; PROTEIN; ALPHA; PROLIFERATION; ZEBRAFISH; SIGNATURE; PATTERNS; Endometrial adenocarcinoma; PTEN; SCUBE2 gene; steroid hormone receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Mar 2020 07:16 |
| Last Modified: | 25 Mar 2020 07:16 |
| URI: | https://pred.uni-regensburg.de/id/eprint/15632 |
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